The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 2010
Filed:
Apr. 05, 2006
Timothy M. Chinowsky, Seattle, WA (US);
Scott D. Soelberg, Seattle, WA (US);
Peter C. Kauffman, Bainbridge Island, WA (US);
Clement E. Furlong, Bainbridge Island, WA (US);
Jared Tritz, Seattle, WA (US);
Michael S. Grow, Bothell, WA (US);
Alexei N. Naimushin, Bellevue, WA (US);
Sinclair S. Yee, Seattle, WA (US);
Timothy M. Chinowsky, Seattle, WA (US);
Scott D. Soelberg, Seattle, WA (US);
Peter C. Kauffman, Bainbridge Island, WA (US);
Clement E. Furlong, Bainbridge Island, WA (US);
Jared Tritz, Seattle, WA (US);
Michael S. Grow, Bothell, WA (US);
Alexei N. Naimushin, Bellevue, WA (US);
Sinclair S. Yee, Seattle, WA (US);
University of Washington, Seattle, WA (US);
Abstract
This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.