The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 2010
Filed:
Jul. 18, 2005
Joseph J. Nunes, Andover, MA (US);
Matthew W. Martin, Cambridge, MA (US);
Ryan White, Somerville, MA (US);
David Mcgowan, Woluwe St. Pierre, BE;
Jean E. Bemis, Arlington, MA (US);
Frank Kayser, San Francisco, CA (US);
Jiasheng Fu, Foster City, CA (US);
Jinqian Liu, Palo Alto, CA (US);
Xianyun Jiao, San Mateo, CA (US);
Joseph J. Nunes, Andover, MA (US);
Matthew W. Martin, Cambridge, MA (US);
Ryan White, Somerville, MA (US);
David McGowan, Woluwe St. Pierre, BE;
Jean E. Bemis, Arlington, MA (US);
Frank Kayser, San Francisco, CA (US);
Jiasheng Fu, Foster City, CA (US);
Jinqian Liu, Palo Alto, CA (US);
XianYun Jiao, San Mateo, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to furanopyridine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.