The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 2010
Filed:
Sep. 23, 2005
Vladimir R. Muzykantov, Warwick, PA (US);
Juan Carlos Murciano, Sevilla, ES;
D. Neil Granger, Shreveport, LA (US);
Vladimir R. Muzykantov, Warwick, PA (US);
Juan Carlos Murciano, Sevilla, ES;
D. Neil Granger, Shreveport, LA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Methods for targeting and prolonging association of a selected drug to the luminal surface of pulmonary vascular endothelium of an animal are provided wherein a selected drug is administered to an animal in combination with a non-internalizable ICAM-1 antibody which binds to an antigen on the luminal surface of the pulmonary vasculature. This method is particularly useful in dissolution of fibrin clots or prevention of the intravascular coagulation in the pulmonary vasculature.