The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 2010
Filed:
Mar. 04, 2005
Applicants:
Tom J. W. Huizinga, Leiden, NL;
Robert C. Hoeben, Leiden, NL;
Rob G. H. H. Nelissen, Leiden, NL;
Andrew Mountain, London, GB;
Inventors:
Tom J. W. Huizinga, Leiden, NL;
Robert C. Hoeben, Leiden, NL;
Rob G. H. H. Nelissen, Leiden, NL;
Andrew Mountain, London, GB;
Assignees:
Innovata Limited, , GB;
Academisch Ziekenhuis Leiden, , NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/70 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention relates to the use of gene therapy in the treatment of aseptic loosening of orthopaedic prostheses and discloses methods of refixing such prostheses without open revision surgery. In particular, it provides adenoviral vectors and prodrugs for simultaneous, separate or sequential use in the destruction of interface tissue allowing subsequent recementing of loose prostheses in a minimally invasive manner.