The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2010
Filed:
Mar. 31, 2000
Arne Holmgren, S-17177 Stockholm, SE;
Marjan H. Amiri, Stockholm, SE;
Hiroyuki Masayasu, Tokyo, JP;
Other;
Abstract
A substrate for thioredoxin reductase which comprises a compound represented by the following general formula (I) or (I'): wherein Rand Rindependently represent a hydrogen atom, a halogen atom, a trifluoromethyl group and the like; Rrepresents an aryl group, an aromatic heterocyclic group and the like; Rrepresents a hydrogen atom, a hydroxyl group, a —S-α-amino acid group and the like; Rrepresents a hydrogen atom or a C-Calkyl group; Y represents oxygen atom or sulfur atom; n represents an integer of from 0 to 5; and the selenium atom may be oxidized, whose example includes 2-phenyl-1,2-benzisoselenazol-3(2H)-one or a ring-opened form thereof. The substrate is reduced by thioredoxin reductase in the presence of NADPH and enhances peroxidase activity of thioredoxin reductase.