The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2010
Filed:
Mar. 12, 2008
Joel Moss, Bethesda, MD (US);
Shunya Oka, Niigata, JP;
Jiro Kato, Rockville, MD (US);
Jianfeng Zhu, Frederick, MD (US);
Atsushi Kasamatsu, Rockville, MD (US);
Joel Moss, Bethesda, MD (US);
Shunya Oka, Niigata, JP;
Jiro Kato, Rockville, MD (US);
Jianfeng Zhu, Frederick, MD (US);
Atsushi Kasamatsu, Rockville, MD (US);
Abstract
This disclosure provides methods for catalyzing the release of ADP-ribose from poly(ADP-ribose) or O-acetyl-ADP-ribose. Also provided are methods for modifying DNA repair or chromatin structure by introducing into the cell an agent that modifies the activity of an ARH3 polypeptide, or variant or fragment thereof. Further provided are methods for screening molecules involved in the poly(ADP-ribosyl)ation of proteins or O-acetyl-ADP-ribose content, and method for treating disorders by altering activity of an ARH3 protein.