The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
Aug. 22, 2007
Anthony P. Malanoski, Greenbelt, MD (US);
Zheng Wang, Burke, VA (US);
Baochuan Lin, Bethesda, MD (US);
David a Stenger, Herndon, VA (US);
Joel M Schnur, Burke, VA (US);
Anthony P. Malanoski, Greenbelt, MD (US);
Zheng Wang, Burke, VA (US);
Baochuan Lin, Bethesda, MD (US);
David A Stenger, Herndon, VA (US);
Joel M Schnur, Burke, VA (US);
The United States of America as represented by the Secretary of the Navy, Washington, DC (US);
Abstract
A computer-implemented method as follows. Providing a list of target sequences associated with one or more organisms. Providing a list of candidate prototype sequences suspected of hybridizing to one or more of the target sequences. Generating a collection of probes corresponding to each candidate prototype sequence, each collection of probes having a set of probes for every subsequence. The sets consist of the corresponding subsequence and every variation of the corresponding subsequence formed by varying a center nucleotide of the corresponding subsequence. Generating a set of fragments corresponding to each target sequence. Calculating the binding free energy of each fragment with a perfect complimentary sequence of the fragment. Determining which extended fragments are perfect matches to any of the probes. Assembling a base call sequence corresponding to each candidate prototype sequence.