The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
Apr. 28, 2006
Applicants:
Zhenyun Peng, Xuzhou, CN;
Wei Zhu, Xuzhou, CN;
Inventors:
Zhenyun Peng, Xuzhou, CN;
Wei Zhu, Xuzhou, CN;
Assignee:
NHWA Pharma Corporation, Xuzhou, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 53/134 (2006.01); C07D 221/20 (2006.01);
U.S. Cl.
CPC ...
Abstract
A process for preparation of gabapentin hydrochloride by converting 1,5-dicyano-2,4-dioxo-3-azaspiro[5,5]-undecane into 1,5-diaminoformyl-2,4-dioxo-3-azaspiro[5,5]-undecane at a temperature of 65° C. to 85° C. in the presence of a strong acid, and then carrying out Hofmann rearrangement under an alkaline condition. The starting material of the process is readily available. The process is simple, and can reduce the purification procedure of intermediates, reduce production cost, and obtain product with higher purity.