The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
Aug. 11, 2004
Hong Fan, Plainsboro, NJ (US);
Edmund R. Marinelli, Lawrenceville, NJ (US);
Palaniappa Nanjappan, Dayton, NJ (US);
Radhakrishna Pillai, Cranbury, NJ (US);
Rolf E. Swenson, Princeton, NJ (US);
Hong Fan, Plainsboro, NJ (US);
Edmund R. Marinelli, Lawrenceville, NJ (US);
Palaniappa Nanjappan, Dayton, NJ (US);
Radhakrishna Pillai, Cranbury, NJ (US);
Rolf E. Swenson, Princeton, NJ (US);
Bracco International B.V., Amsterdam, NL;
Abstract
Methods for the preparation of multivalent constructs for therapeutic and diagnostic applications are provided. More specifically, novel methods for preparing multivalent constructs comprising the formula A-B-C-D-E-B'-F for therapeutic and diagnostic applications are provided which use a novel linker D comprising, in various embodiments, a dicarboxylic acid derivative such as, e.g., a glutaric acid bis N-hydroxysuccinimidyl ester or a derivative thereof; or a diamine derivative. The remaining components in the multivalent construct A-B-C-D-E-B′-F are defined as follows: A is a first peptide, B is a first branching group, C is an optional first spacer, E is an optional second spacer which may be the same as or different from said first spacer C, B′ is an optional second branching group which may be the same as or different from said first branching group B, and F is a second peptide which may be the same as or different from said first peptide A.