The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
Jun. 20, 2008
Muhammad Hashim Javaid, Cambridge, GB;
Graeme Cameron Murray Smith, Cambridge, GB;
Niall Morrison Barr Martin, Cambridge, GB;
Sylvie Gomez, Cambridge, GB;
Vincent Junior Ming-iai Loh, Cambridge, GB;
Xiao-ling Fan Cockcroft, Cambridge, GB;
Stefano Forte, Cambridge, GB;
Keith Allan Menear, Cambridge, GB;
Ian Timothy William Matthews, Cambridge, GB;
Frank Kerrigan, Tintagel, GB;
Muhammad Hashim Javaid, Cambridge, GB;
Graeme Cameron Murray Smith, Cambridge, GB;
Niall Morrison Barr Martin, Cambridge, GB;
Sylvie Gomez, Cambridge, GB;
Vincent Junior Ming-Iai Loh, Cambridge, GB;
Xiao-Ling Fan Cockcroft, Cambridge, GB;
Stefano Forte, Cambridge, GB;
Keith Allan Menear, Cambridge, GB;
Ian Timothy William Matthews, Cambridge, GB;
Frank Kerrigan, Tintagel, GB;
Maybridge Limited, Cornwall, GB;
Abstract
A compound of formula (I): for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NRor CRR; if X═NRthen n is 1 or 2 and if X═CRRthen n is 1; Ris selected from the group consisting of H, optionally substituted Calkyl, Caryl, Cheterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; Ris selected from H, hydroxy, amino; or Rand Rmay together form a spiro-Ccycloalkyl or heterocyclyl group; Rand Rare independently selected from the group consisting of hydrogen and Calkyl, or when X is CRR, R, R, R, Rand R, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; Ris selected from H and halo; and Het is selected from: where Yis selected from CH and N, Yis selected from CH and N, Yis selected from CH, CF and N, where only one or two of Y, Yand Ycan be N; and where Q is O or S.