The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
Mar. 25, 2009
Charles Z. Ding, Foster City, CA (US);
Genliang LU, Winchester, MA (US);
Keith Combrink, Arlington, TX (US);
Dianjun D. Chen, Houston, TX (US);
Minsoo Song, Dobbs Ferry, NY (US);
Jiancheng Wang, Revere, MA (US);
Zhenkun MA, Westfield, NJ (US);
Brian Desmond Palmer, Waitakere, NZ;
Adrian Blaser, Waitakere, NZ;
Andrew M. Thompson, Auckland, NZ;
Iveta Kmentova, Jahodna, SK;
Hamish Scott Sutherland, Auckland, NZ;
William Alexander Denny, Auckland, NZ;
Charles Z. Ding, Foster City, CA (US);
Genliang Lu, Winchester, MA (US);
Keith Combrink, Arlington, TX (US);
Dianjun D. Chen, Houston, TX (US);
Minsoo Song, Dobbs Ferry, NY (US);
Jiancheng Wang, Revere, MA (US);
Zhenkun Ma, Westfield, NJ (US);
Brian Desmond Palmer, Waitakere, NZ;
Adrian Blaser, Waitakere, NZ;
Andrew M. Thompson, Auckland, NZ;
Iveta Kmentova, Jahodna, SK;
Hamish Scott Sutherland, Auckland, NZ;
William Alexander Denny, Auckland, NZ;
Global Alliance for TB Drug Development, New York, NY (US);
Abstract
The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as