The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
May. 31, 2007
Applicants:
Ronggai Sun, Ellicott City, MD (US);
David Michael Hone, Rockville, MD (US);
Jerald C. Sadoff, Washington, DC (US);
Inventors:
Ronggai Sun, Ellicott City, MD (US);
David Michael Hone, Rockville, MD (US);
Jerald C. Sadoff, Washington, DC (US);
Assignee:
Aeras Global TB Vaccine Foundation, Bethesda, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/12 (2006.01);
U.S. Cl.
CPC ...
Abstract
strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8T cell immune response are provided. Thestrains are genetically engineered to express: a endosomolytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of thefrom endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing suchstrains.