The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
Sep. 11, 2007
Rainer Muller, Penzberg, DE;
Stephan Glaser, Seeshaupt, DE;
Frank Geipel, Penzberg, DE;
Johann-peter Thalhofer, Weilheim, DE;
Bernhard Rexer, Weilhem, DE;
Claus Schneider, Eppelheim, DE;
Michael Ratka, Mannheim, DE;
Stephanie Ronning, Penzberg, DE;
Hellmut Eckstein, Weilheim, DE;
Claudia Giessel, Greiling, DE;
Rainer Muller, Penzberg, DE;
Stephan Glaser, Seeshaupt, DE;
Frank Geipel, Penzberg, DE;
Johann-Peter Thalhofer, Weilheim, DE;
Bernhard Rexer, Weilhem, DE;
Claus Schneider, Eppelheim, DE;
Michael Ratka, Mannheim, DE;
Stephanie Ronning, Penzberg, DE;
Hellmut Eckstein, Weilheim, DE;
Claudia Giessel, Greiling, DE;
Roche Diagnostics Operations, Inc., Indianapolis, IN (US);
Abstract
The present invention concerns a method for producing recombinant trypsin from porcine pancreas inwhich is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to β-trypsin and autolysis of β-trypsin by α-trypsin into ε-trypsin and from there into inactive peptides.