The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
Aug. 21, 2006
Hsien-jue Chu, Fort Dodge, IA (US);
Wumin LI, Fort Dodge, IA (US);
Zhichang Xu, Fort Dodge, IA (US);
Hsien-Jue Chu, Fort Dodge, IA (US);
Wumin Li, Fort Dodge, IA (US);
Zhichang Xu, Fort Dodge, IA (US);
Wyeth LLC, Madison, NJ (US);
Abstract
The invention provides an improvedbacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivatedbacterin and an adjuvant mixture, which, in combination, provide immunity frominfection after a single administration, and elicit an immune response specific tobacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably CARBOPOL®, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polyoxypropylene block copolymer such as PLURONIC®. The vaccine composition may optionally include a preservative, preferably thimerosol and/or EDTA.