The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2010
Filed:
Jun. 14, 2006
Lu-yong Wang, Plainsboro, NJ (US);
Zhuowen Tu, San Diego, CA (US);
Daniel Fasulo, Titusville, NJ (US);
Dorin Comaniciu, Princeton Junction, NJ (US);
Lu-yong Wang, Plainsboro, NJ (US);
Zhuowen Tu, San Diego, CA (US);
Daniel Fasulo, Titusville, NJ (US);
Dorin Comaniciu, Princeton Junction, NJ (US);
Siemens Corporation, Iselin, NJ (US);
Abstract
A program storage device is provided readable by machine, tangibly embodying a program of instructions executable by the machine to perform method steps for classification of biological tissue by gene expression profiling. The method steps include providing a training set of gene expression profiles of known tissue samples, providing a first-layer strong classifier of the known tissue samples by combining weak classifiers using boosting, creating two sample sets based on the first classifier, populating the two sample sets with a next-layer of classifiers based on a previous-layer classifier, organizing the classifiers in a tree data structure, and outputting the tree data structure as a probabilistic boosting tree classifier for tissue sample classification and disease subtype discovery. A multi-class diagnosis problem is transformed to a two-class diagnosis process by finding an optimal feature and dividing the multi-class problem into two-classes.