The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2010
Filed:
Nov. 26, 2003
Kenneth D. James, Mebane, NC (US);
Balasingam Radhakrishnan, Chapel Hill, NC (US);
Navdeep B. Malkar, Cary, NC (US);
Mark A. Miller, Raleigh, NC (US);
Nnochiri N. Ekwuribe, Cary, NC (US);
Kenneth D. James, Mebane, NC (US);
Balasingam Radhakrishnan, Chapel Hill, NC (US);
Navdeep B. Malkar, Cary, NC (US);
Mark A. Miller, Raleigh, NC (US);
Nnochiri N. Ekwuribe, Cary, NC (US);
Biocon Limited, , IN;
Abstract
Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, subcutaneous, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.