The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2010
Filed:
Jan. 11, 2007
Sergio Riva, Seveso, IT;
Paola Fassi, Vittuone, IT;
Michele Scarpellini, Bergamo, IT;
Pietro Allegrini, San Donato Milanese, IT;
Gabriele Razzetti, Sesto S. Giovanni, IT;
Sergio Riva, Seveso, IT;
Paola Fassi, Vittuone, IT;
Michele Scarpellini, Bergamo, IT;
Pietro Allegrini, San Donato Milanese, IT;
Gabriele Razzetti, Sesto S. Giovanni, IT;
Dipharma Francis s.r.l., Baranzate, IT;
Abstract
A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof wherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R,S) enantiomers, or a salt thereof, wherein Ris straight or branched C-Calkyl, optionally substituted with phenyl; (the asterisk * and R defined above), with a lipase from, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.