The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2010
Filed:
Oct. 19, 2005
Peter Findeisen, Schriesheim, DE;
Sabine Merx, St. Leon-Rot, DE;
Matthias Kloor, Ludwigshafen, DE;
Magnus Von Knebel Doeberitz, Heidelberg, DE;
Peter Findeisen, Schriesheim, DE;
Sabine Merx, St. Leon-Rot, DE;
Matthias Kloor, Ludwigshafen, DE;
Magnus Von Knebel Doeberitz, Heidelberg, DE;
MTM Laboratories, AG, Heidelberg, DE;
Abstract
The present invention provides a method for assessment of the Microsatellite Instability (MSI) status of medically relevant conditions associated with MSI phenotype such as e.g. neoplastic lesions. The method is based on the analysis of a monomorphic T25 (CAT25) mononucleotide repeat located in the 3'-UTR of the Caspase 2 (CASP2) gene. Based on the determination of the length of the named mononucleotide repeat the presence or absence of MSI may be assessed. Determination of the length is performed in a single PCR procedure. Alternatively an enhanced assessment could be performed by combining the CAT25 marker with further markers such as BAT25 and BAT26 in a single multiplex PCR process.