The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2010
Filed:
Aug. 12, 2005
Shari M. Ling, Ellicott City, MD (US);
Lorah Perlee, Wilton, CT (US);
Velizar T. Tchernev, Sofia, BG;
Serguei Lejnine, Mercer Island, WA (US);
Dhavalkumar D. Patel, Chapel Hill, NC (US);
Luigi Ferrucci, Baltimore, MD (US);
Ming Zhan, Germantown, MD (US);
Shari M. Ling, Ellicott City, MD (US);
Lorah Perlee, Wilton, CT (US);
Velizar T. Tchernev, Sofia, BG;
Serguei Lejnine, Mercer Island, WA (US);
Dhavalkumar D. Patel, Chapel Hill, NC (US);
Luigi Ferrucci, Baltimore, MD (US);
Ming Zhan, Germantown, MD (US);
Abstract
Methods are provided for evaluating osteoarthritis (OA), for example for diagnosing OA, to confirm a diagnosis of OA, to assess or prognose progression of OA, determining the severity of a subject who has OA, and determining a subject's risk of developing OA in the future, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes determining an amount of activity (such as an amount of protein present or an amount of expression) of OA risk-related molecules, such as soluble vascular adhesion protein 1 (sVAP-1) or interleukin-15 (IL-15). Also provided are methods of identifying one or more compounds that alter the activity of an OA-related molecule, thereby identifying potential anti-osteoarthritis drugs.