The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2010
Filed:
Apr. 11, 2003
Stephan R. Targan, Santa Monica, CA (US);
Eric A. Vasiliauskas, Manhattan Beach, CA (US);
William S. Mow, Culver City, CA (US);
Huiying Yang, Cerritos, CA (US);
Phillip R. Fleshner, Beverly Hills, CA (US);
Jerome I. Rotter, Los Angeles, CA (US);
Stephan R. Targan, Santa Monica, CA (US);
Eric A. Vasiliauskas, Manhattan Beach, CA (US);
William S. Mow, Culver City, CA (US);
Huiying Yang, Cerritos, CA (US);
Phillip R. Fleshner, Beverly Hills, CA (US);
Jerome I. Rotter, Los Angeles, CA (US);
Cedars-Sinai Medical Center, Los Angeles, CA (US);
Abstract
The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.