The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2010
Filed:
Mar. 24, 2005
Vanitha Ramakrishnan, Belmont, CA (US);
Vinay Bhaskar, San Francisco, CA (US);
Sun Ho, Fremont, CA (US);
Richard Murray, Cupertino, CA (US);
Debbie Law, San Francisco, CA (US);
Vanitha Ramakrishnan, Belmont, CA (US);
Vinay Bhaskar, San Francisco, CA (US);
Sun Ho, Fremont, CA (US);
Richard Murray, Cupertino, CA (US);
Debbie Law, San Francisco, CA (US);
Facet Biotech Corporation, Redwood City, CA (US);
Abstract
The present invention provides methods for direct killing of cancer cells using anti-α5β1 antibodies. Generally, the method comprises contacting a cancer cell that expresses α5β1 on its surface with an anti-α5β1 antibody, and thereby inducing the death of the cancer cell. The methods of the invention may be employed at an early stage of cancer development in a patient to prevent tumor establishment. In addition, the methods may be used to treat previously formed tumors especially in cancer that have not proven susceptible to anti-angiogenesis therapy. The methods may be employed as a combination therapy of anti-α5β1 antibodies together with cancer chemotherapeutic agents or other molecular-based cancer therapeutic agents.