The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 16, 2010
Filed:
Feb. 07, 2008
Klaus Bosslet, Marburg, DE;
Gerhard Seemann, Marburg, DE;
Hans Harald Sedlacek, Marburg, DE;
Bernhard Auerbach, Marburg, DE;
Klaus Bosslet, Marburg, DE;
Gerhard Seemann, Marburg, DE;
Hans Harald Sedlacek, Marburg, DE;
Bernhard Auerbach, Marburg, DE;
Aventis Pharma Deutschland GmbH, Frankfurt, DE;
Abstract
The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or 'humanized' MAbs are obtained by inserting the hypervariable regions (complementarity determining regions=CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.