The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2010
Filed:
Feb. 11, 2005
David Spencer, Chapel Hill, NC (US);
Lynn F. Dickey, Cary, NC (US);
John R. Gasdaska, Carrboro, NC (US);
Xiaowei Wang, Carrboro, NC (US);
Kevin M. Cox, Raleigh, NC (US);
Charles G. Peele, Apex, NC (US);
David Spencer, Chapel Hill, NC (US);
Lynn F. Dickey, Cary, NC (US);
John R. Gasdaska, Carrboro, NC (US);
Xiaowei Wang, Carrboro, NC (US);
Kevin M. Cox, Raleigh, NC (US);
Charles G. Peele, Apex, NC (US);
Biolex Therapeutics, Inc., Pittsboro, NC (US);
Abstract
The present invention provides methods and compositions for the production of recombinant plasminogen, microplasminogen, and fragments thereof in a duckweed expression system. It is the novel finding of the present invention that a duckweed expression system may be used to produce high levels of plasminogen and microplasminogen. The duckweed-produced plasminogen and microplasminogen can be activated to produce a polypeptide having protease activity. Thus, the invention encompasses methods for the expression of plasminogen, microplasminogen, and fragments thereof in duckweed, duckweed plants that are transformed with expression cassettes for the expression of plasminogen, microplasminogen, and fragments thereof, and nucleic acids comprising nucleotide sequences encoding plasminogen, microplasminogen, and fragments thereof, where these nucleotide sequences are modified to enhance their expression in duckweed.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile