The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2010
Filed:
Sep. 20, 2004
Jun Takehara, Kanagawa, JP;
Jingping Qu, Kanagawa, JP;
Kazuaki Kanno, Kanagawa, JP;
Hiroshi Kawabata, Kanagawa, JP;
Yasumasa Dekishima, Kanagawa, JP;
Makoto Ueda, Kanagawa, JP;
Kyoko Endo, Kanagawa, JP;
Takeshi Murakami, Kanagawa, JP;
Tomoko Sasaki, Kanagawa, JP;
Hisatoshi Uehara, Kanagawa, JP;
Youichi Matsumoto, Kanagawa, JP;
Shihomi Suzuki, Kanagawa, JP;
Jun Takehara, Kanagawa, JP;
Jingping Qu, Kanagawa, JP;
Kazuaki Kanno, Kanagawa, JP;
Hiroshi Kawabata, Kanagawa, JP;
Yasumasa Dekishima, Kanagawa, JP;
Makoto Ueda, Kanagawa, JP;
Kyoko Endo, Kanagawa, JP;
Takeshi Murakami, Kanagawa, JP;
Tomoko Sasaki, Kanagawa, JP;
Hisatoshi Uehara, Kanagawa, JP;
Youichi Matsumoto, Kanagawa, JP;
Shihomi Suzuki, Kanagawa, JP;
Mitsubishi Chemical Corporation, Tokyo, JP;
Abstract
The object of the present invention is to provide 3-hydroxy-3-(2-thienyl)propionamides useful as synthesis intermediates of pharmaceutical preparations and the like and a method for obtaining optically active 3-amino-1-(2-thienyl)-1-propanols using the same with high reaction yield, high optical yield and industrially low cost. According to the present invention, 3-amino-1-(2-thienyl)-1-propanols are obtained by carrying out asymmetric reduction of a β-ketocarbonyl compound having thiophene ring in the presence of a catalyst constituted from a compound of a group VIII or IX metal in the periodic table (e.g., a ruthenium compound) and an asymmetric ligand represented by a specified optically active diamine derivative (e.g., a diphenylethylenediamine derivative), or using a cell, a treated product of said cell or the like of a microorganism, and as occasion demands, carrying out amidation of the ester group and then carrying out reduction of the amido group. (each of the substituents is as described in claim).