The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2010
Filed:
Feb. 14, 2007
Applicants:
Vladimir Naddaka, Petach Tikva, IL;
Shady Saeed, Haifa, IL;
Stephen Cherkez, Caesarea, IL;
Oded Arad, Rehovot, IL;
Inventors:
Vladimir Naddaka, Petach Tikva, IL;
Shady Saeed, Haifa, IL;
Stephen Cherkez, Caesarea, IL;
Oded Arad, Rehovot, IL;
Assignee:
Chemagis Ltd., Bnei Brak, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/12 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides a process for preparing highly pure 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (imiquimod). The process preferably includes heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with ammonia in a polar aprotic solvent at relatively moderate pressure to produce imiquimod, and optionally purifying the imiquimod. The process of the present invention can produce highly pure imiquimod in high yield.