The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2010
Filed:
Mar. 30, 2006
Roberto Gambari, Bologna, IT;
Letizia Penolazzi, Ferrara, IT;
Roberta Piva, Ferrara, IT;
Universita' Degli Studi di Ferrara, Ferrara, IT;
Associazione Veneta per la Lotta Alla Talassemia, Rovigo, IT;
Abstract
The invention relates to a synthetic double-stranded oligonucleotide capable of modifying the molecular phenotype of osteoclasts and increasing the expression of the oestrogen alpha receptor gene. Pharmaceutical compositions comprising the oligonucleotide according to the invention are also described, as well as therapeutic applications of that oligonucleotide, in particular for the treatment of osteopenic diseases such as for example osteoporosis. The oligonucleotide according to the invention is characterized in that it comprises the sequence 5'-ATTTATTTTCAATACTGACT-3′ (SEQ ID NO: 1) or a fragment or a mutant thereof.