The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2010
Filed:
Dec. 14, 2005
Applicants:
Bao-lu Chen, San Ramon, CA (US);
Chin-yi Huang, Fremont, CA (US);
Inventors:
Bao-lu Chen, San Ramon, CA (US);
Chin-Yi Huang, Fremont, CA (US);
Assignee:
Novartis Vaccines and Diagnostics, Emeryville, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Stabilized aqueous compositions of tissue factor pathway inhibitor (TFPI) or TFPI variants comprise a solubilizing agent, an antioxidant, and a buffer. The combination of a solubilizing agent and an antioxidant can lead to a significant improvement in the storage life of TFPI or TFPI variant compositions. The solubilizing agent and antioxidant substantially counteract the effects of TFPI or TFPI variant degradation through aggregation and oxidation.