The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 09, 2010
Filed:
Dec. 19, 2007
Bruce A. Green, New City, NY (US);
Randall K. Holmes, Golden, CO (US);
Michael G. Jobling, Aurora, CO (US);
Duzhang Zhu, Pomona, NY (US);
Bruce A. Green, New City, NY (US);
Randall K. Holmes, Golden, CO (US);
Michael G. Jobling, Aurora, CO (US);
Duzhang Zhu, Pomona, NY (US);
Wyeth Holdings Corporation, Madison, NJ (US);
The United States of America, as represented by the Uniformed Services University of Health Sciences, Washington, DC (US);
Abstract
Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.