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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7655649 B1

PDFFull Text
Date of Patent:
Feb. 02, 2010

Filed:

Apr. 05, 2005

Inhibitors of akt activity

Applicants:

Mark T. Bilodeau, Lansdale, PA (US);

Peter C. Chua, San Diego, CA (US);

Nicholas D. P. Cosford, San Diego, CA (US);

Jacob M. Hoffman, Lansdale, PA (US);

Johnny Yasuo Nagasawa, San Diego, CA (US);

Inventors:

Mark T. Bilodeau, Lansdale, PA (US);

Peter C. Chua, San Diego, CA (US);

Nicholas D. P. Cosford, San Diego, CA (US);

Jacob M. Hoffman, Lansdale, PA (US);

Johnny Yasuo Nagasawa, San Diego, CA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Matthew A. Leff

David A. Muthard

Primary Examiner:

Mark L Berch

Assistant Examiner:

Cecilia M Jaisle

Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 403/10 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 498/04 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 279/12 (2006.01); C07D 295/00 (2006.01); C07D 237/08 (2006.01); C07D 237/10 (2006.01); C07D 401/10 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); C07D 239/24 (2006.01); C07D 239/28 (2006.01); C07D 265/16 (2006.01); C07D 487/04 (2006.01); C07D 317/12 (2006.01); C07F 5/04 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

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