The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2010
Filed:
Oct. 31, 2007
Dennis P. Curran, Pittsburgh, PA (US);
Hubert Josien, Jersey City, NJ (US);
Bom David, Pittsburgh, PA (US);
Dennis P. Curran, Pittsburgh, PA (US);
Hubert Josien, Jersey City, NJ (US);
Bom David, Pittsburgh, PA (US);
University of Pittsburgh - of The Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
A method of inhibiting topoisomerase I mediated DNA cleavage including administering a pharmaceutically effective amount of a compound having the following formula or a pharmaceutically acceptable salt thereof: wherein Rand Rare independently the same or different and are hydrogen, an alkyl group, an aminoalkyl group, an alkylaminoalkyl group, a haloalkyl group, a hydroxyalkyl group, an alkenyl group, an alkynyl group, an alkoxyl group, an aryloxy group, a carbamoyloxy group, a halogen, a hydroxyl group, a nitro group, a cyano group, an azido group, a formyl group, a hydrazino group, —C(O)R, an amino group, an alkylamino group, a dialkylamino group, —SR, or Rand Rtogether form a group of the formula —O(CH)O— wherein n represents the integer 1 or 2; Ris H, F, a halogen atom, a nitro group, an amino group, a hydroxyl group, or a cyano group; or Rand R3 together form —O(CH)O— (n=1 or 2); Ris H, F, a Calkyl group, a Calkenyl group, a Calkynyl group, or a Calkoxyl group; Ris a Calkyl group, or a propargyl group.