The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2010
Filed:
Dec. 19, 2003
Knut Adermann, Hannover, DE;
Frank Kirchhoff, Ulm, DE;
Jan Münch, Ulm, DE;
Axel Schulz, Hannover, DE;
Knut Adermann, Hannover, DE;
Frank Kirchhoff, Ulm, DE;
Jan Münch, Ulm, DE;
Axel Schulz, Hannover, DE;
IPF Pharmaceuticals GmbH, Hannover, DE;
Abstract
The invention relates to peptides with biological activity against infection having the amino acid sequence Z-LE-X-IP-X-X-X-P-X-X-X-X-X-X-K-X-X-X-X-X-Z, wherein Xis a lysine, alanine, or aspartic acid; Xis a cysteine, methionine or isoleucine; Xis a serine, cysteine, lysine or glycine; Xis an isoleucine, alanine, phenylalanine or cysteine; Xis a proline, D-proline or a substituted L- or D-proline; Xis a cysteine or glutamic acid; Xis an amino acid with a hydrophobic or an aromatic side chain or cysteine; Xis an amino acid with a hydrophobic or an aromatic side chain or cysteine; Xis an amino acid with an aromatic side chain; Xis a glycine, alanine or asparagine; Xis a proline, aspartic acid, octahydroindolyl-2-carboxylic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Xis a phenylalanine, alanine, glycine, glutamic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Xis an amino acid with a hydrophobic or an aromatic side chain; Xis an amino acid with a hydrophobic or an aromatic side chain; Xis a phenylalanine or deletion; Zis NHor a sequence of 1 to 10 amino acid residues; Zis COOH or a sequence of 1 to 10 amino acid residues; and peptides which are fragments and/or covalently linked oligomers and/or derivatives, especially amidated, alkylated, acylated, sulfated, pegylated, phosphorylated and/or glycosylated derivatives, and mutants thereof, and with the provisio that (a) if Xis alanine, glycine, glutamic acid, or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid than X, Xand Xare phenylalanine, valine and phenylalanine respectively; and/or (b) if Xis phenylalanine, than X, Xand Xare valine, phenylalanine and a deletion, respectively; and (c) that there are at maximum two cysteine residues in a peptide.