The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2010
Filed:
Aug. 02, 2001
Joerg Meyer, Heusenstamm, DE;
Berthold Nies, Fraenkisch-Crumbach, DE;
Michel Dard, Seeheim-Jugenheim, DE;
Guenter Hoelzemann, Seeheim-Jugenheim, DE;
Horst Kessler, Schwalbach, DE;
Martin Kantlehner, Freising, DE;
Ulrich Hersel, Erlabrunn, DE;
Christoph Gibson, Ihringen, DE;
Gabor Sulyok, Munich, DE;
Joerg Meyer, Heusenstamm, DE;
Berthold Nies, Fraenkisch-Crumbach, DE;
Michel Dard, Seeheim-Jugenheim, DE;
Guenter Hoelzemann, Seeheim-Jugenheim, DE;
Horst Kessler, Schwalbach, DE;
Martin Kantlehner, Freising, DE;
Ulrich Hersel, Erlabrunn, DE;
Christoph Gibson, Ihringen, DE;
Gabor Sulyok, Munich, DE;
Biomet Deutschland GmbH, Berlin, DE;
Abstract
The invention relates to compounds of formula (1) B-Q-X, wherein B is bioactive cell adhesive mediating molecule. Q is absent or is an inorganic spacer molecule and Xis an anchor molecule, selected from the group Lys-(CO—CH—(CH)—POH)(I), -Lys-[-Lys-(CO—CH—(CH)—POH)](ii) or -Lys-(Lys[-Lys-(CO—CH—(CH)—POH](iii), and n independently represents 0, 1, 2 or 3, wherein a free amino group of group B is linked in peptide form to a free carboxyl group of the spacer molecule Q or of the anchor molecule X, or a free amino group of the radical Q is linked in peptide form to a free carboxyl group of the radical X. The invention also relates to the salts thereof. The inventive compounds can be used as integrin inhibitors for the treatment of illnesses, deficiencies, inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.