The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 02, 2010

Filed:

Nov. 15, 2004
Applicants:

Jeffrey S. Chamberlain, Seattle, WA (US);

Paul Gregorevic, Seattle, WA (US);

Michael J. Blankinship, Seattle, WA (US);

James M. Allen, Seattle, WA (US);

Inventors:

Jeffrey S. Chamberlain, Seattle, WA (US);

Paul Gregorevic, Seattle, WA (US);

Michael J. Blankinship, Seattle, WA (US);

James M. Allen, Seattle, WA (US);

Assignee:

The University of Washington, Seattle, WA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 48/00 (2006.01); A61K 31/70 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides systemic nucleic acid sequence delivery without conventional systemic administration aids (SAAs). In certain embodiments, vascular permeability agents (VPAs), such as VEGF, are used in conjunction with nucleic acid viral vectors, such as adeno-associated virus (AAV). The present invention also provides methods of treating disease by co-administration of nucleic cid sequences encoding Igf-1 and dystrophin or dystrophin-like proteins.


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