The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 02, 2010
Filed:
May. 10, 2006
Ulrich Brennscheidt, Riehen, CH;
Otmar Herrgott, Legal Representative, Freiburg, DE;
Astrid Heller, Penzberg, DE;
Verena Lutz, Munich, DE;
Joachim Moecks, Mannheim, DE;
Carol Ward, Helfrantzkirch, FR;
Ulrich Brennscheidt, Riehen, CH;
Otmar Herrgott, legal representative, Freiburg, DE;
Astrid Heller, Penzberg, DE;
Verena Lutz, Munich, DE;
Joachim Moecks, Mannheim, DE;
Carol Ward, Helfrantzkirch, FR;
Hoffman La-Roche Inc., Nutley, NJ (US);
Abstract
The present invention relates to a method of determining whether a biological sample comprising human lung cancer cells is sensitive to a combination of an epidermal growth factor receptor inhibitor and a chemotherapeutic agent by determining the overexpression of a phosphorylated AKT protein and/or a phosphorylated MAPK protein in the biological sample. The invention is also related to methods for deriving a candidate agent or for selecting a composition for inhibiting the progression of lung cancer in a patient wherein a phosphorylated AKT protein and/or a phosphorylated MAPK protein is used.