The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2010
Filed:
Jun. 13, 2002
Daniel S. Sem, San Diego, CA (US);
Maurizio Pellecchia, San Diego, CA (US);
Qing Dong, San Diego, CA (US);
Mark Kelly, San Diego, CA (US);
Min S. Lee, Carlsbad, CA (US);
Daniel S. Sem, San Diego, CA (US);
Maurizio Pellecchia, San Diego, CA (US);
Qing Dong, San Diego, CA (US);
Mark Kelly, San Diego, CA (US);
Min S. Lee, Carlsbad, CA (US);
Triad Liquidating Company LLC, Rancho Santa Fe, CA (US);
Abstract
The invention provides a method for obtaining a binding compound for a protein family, wherein the members of the protein family bind a common ligand. The method includes the steps of (a) providing a sample containing a protein from the protein family, a first ligand and a second ligand under conditions wherein the first ligand, the second ligand and the protein form a bound complex; (b) detecting magnetization transfer between the first ligand and the second ligand in the bound complex, thereby determining that the two ligands are proximal in the bound complex; and (c) obtaining a candidate binding compound including the first ligand, or a fragment thereof linked to the second ligand, or a homolog thereof, whereby the population contains binding compounds that bind to members of the protein family.