The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2010
Filed:
Aug. 29, 2008
Shoujun Chen, Billerica, MA (US);
Lijun Sun, Harvard, MA (US);
Zhi-qiang Xia, Dedham, MA (US);
Keizo Kova, Brookline, MA (US);
Mitsunori Ono, Lexington, MA (US);
Shoujun Chen, Billerica, MA (US);
Lijun Sun, Harvard, MA (US);
Zhi-Qiang Xia, Dedham, MA (US);
Keizo Kova, Brookline, MA (US);
Mitsunori Ono, Lexington, MA (US);
Synta Pharmaceuticals Corp., Lexington, MA (US);
Abstract
Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represented by Structural Formula (II): In Structural Formulas (I)-(II), Rand Rare independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When Ris an aryl group or a substituted aryl group, then Ris a hydrazine protecting group; and when Ris an aliphatic or substituted aliphatic group, then Ris —H or a hydrazine protecting group. Ris —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.