Compounds, pharmaceutical compositions containing same, and methods of use for same

Abstract

A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IV wherein R=H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CHOR, —C(O)R, —CO(O)R, —C(O)NRR, —CHC(O)R, or —CHC(O)NHR, where Rand Rare each independently H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R=—OH, —OR, —OCHC(O)R, —OCHC(O)NHR, —OC(O)R, —OC(O)OR, —OC(O)NHNH—R, or —OC(O)NRR, where Rand Rare each independently H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where Rand Rcan each optionally contain halogen atoms; Rand R, the same or different from each other, are C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1.