The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 19, 2010

Filed:

Jul. 09, 2003
Applicants:

Francis P. Kuhajda, Baltimore, MD (US);

Susan M. Medghalchi, Baltimore, MD (US);

Jill M. Mcfadden, Baltimore, MD (US);

Jagan Thupari, Baltimore, MD (US);

Inventors:

Francis P. Kuhajda, Baltimore, MD (US);

Susan M. Medghalchi, Baltimore, MD (US);

Jill M. McFadden, Baltimore, MD (US);

Jagan Thupari, Baltimore, MD (US);

Assignees:

FASgen, Inc., Baltimore, MD (US);

Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/381 (2006.01); C07D 333/32 (2006.01);
U.S. Cl.
CPC ...
Abstract

A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IV wherein R=H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CHOR, —C(O)R, —CO(O)R, —C(O)NRR, —CHC(O)R, or —CHC(O)NHR, where Rand Rare each independently H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R=—OH, —OR, —OCHC(O)R, —OCHC(O)NHR, —OC(O)R, —OC(O)OR, —OC(O)NHNH—R, or —OC(O)NRR, where Rand Rare each independently H, C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where Rand Rcan each optionally contain halogen atoms; Rand R, the same or different from each other, are C-Calkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1.


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