The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 19, 2010

Filed:

Apr. 09, 2007
Applicants:

Dhanapalan Nagarathnam, Bethany, CT (US);

Uday Khire, Hamden, CT (US);

Davoud Asgari, Plainsboro, NJ (US);

Jianxing Shao, Cheshire, CT (US);

Xiao-gao Liu, New Haven, CT (US);

Chunguang Wang, Hamden, CT (US);

Barry Hart, Mountain View, CA (US);

Olaf Weber, Woodbridge, CT (US);

Mark Lynch, Madison, CT (US);

Lei Zhang, Hamden, CT (US);

Lei Wang, New Haven, CT (US);

Inventors:

Dhanapalan Nagarathnam, Bethany, CT (US);

Uday Khire, Hamden, CT (US);

Davoud Asgari, Plainsboro, NJ (US);

Jianxing Shao, Cheshire, CT (US);

Xiao-Gao Liu, New Haven, CT (US);

Chunguang Wang, Hamden, CT (US);

Barry Hart, Mountain View, CA (US);

Olaf Weber, Woodbridge, CT (US);

Mark Lynch, Madison, CT (US);

Lei Zhang, Hamden, CT (US);

Lei Wang, New Haven, CT (US);

Assignee:

Bayer Healthcare LLC, Tarrytown, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 495/04 (2006.01); C07D 251/16 (2006.01); C07D 413/10 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 31/53 (2006.01); A61K 31/497 (2006.01); A61K 31/496 (2006.01); A61K 31/498 (2006.01); A61P 9/12 (2006.01); A61P 9/10 (2006.01); A61P 35/04 (2006.01); A61P 11/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.


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