The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 2010
Filed:
May. 20, 2004
William Butler Cowden, Kambah, AU;
Gavin James Bartell, Conder, AU;
Bart Michael Eschler, Giralang, AU;
Darren Ray March, Banks, AU;
Alan Robertson, Warrawee, AU;
William Butler Cowden, Kambah, AU;
Gavin James Bartell, Conder, AU;
Bart Michael Eschler, Giralang, AU;
Darren Ray March, Banks, AU;
Alan Robertson, Warrawee, AU;
Pharmaxis Pty Limited, French Forest NSW, AU;
Abstract
Novel phosphotetrahydropyran compounds that mimic mannose-6-phosphate but that are more resistant to phosphatases and mannosidases, and pharmaceutical compositions thereof, are disclosed. These compounds and compositions inhibit T lymphocyte migration from blood to tissues or to other extravascular sites. By inhibiting such migration, these compounds are useful for treating diseases or disorders that are mediated at least in part by such T lymphocyte migration. Such diseases and disorders include rheumatoid arthritis, multiple sclerosis, acute disseminated encephalomyelitis, psoriasis, inflammatory bowel disease, T cell-mediated dermatitis, stromal keratitis, uveitis, thyroiditis, sialitis and type I diabetes.