The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 2010
Filed:
Nov. 24, 2003
Roberto DE Campos Giordano, São Carlos, BR;
Raquel DE Lima Camargo Giordano, São Carlos, BR;
Andrea Lopes DE Oliveira Ferreira, São Carlos, BR;
Roberto de Campos Giordano, São Carlos, BR;
Raquel de Lima Camargo Giordano, São Carlos, BR;
Andrea Lopes de Oliveira Ferreira, São Carlos, BR;
Fundacao Universidade Federal de Sao Carlos, Sao Carlos, BR;
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Sao Paulo, BR;
Abstract
The purpose of the present invention is to provide a process for protection of enzymatic biocatalysts, constituted by a primary support, wrapped by a secondary matrix. More particularly, the invention is embodied as a bioreactor with a configuration that preserves the physical integrity and catalytic activity of the biocatalyst after long runs, and at the same time allows an easy separation of the protected biocatalyst from the solid, precipitated during the reaction course. Still more particularly, the invention refers to the use of the bioreactor herein described for the enzymatic synthesis of β-lactam antibiotics, including the insoluble enzymatic catalysts, which have a primary matrix for immobilization involved by a secondary matrix, which is able to preserve 100% of the catalyst physical integrity and approximately 100% of its catalytic activity.