The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 12, 2010

Filed:

Jun. 22, 2007
Applicants:

Gregory Martin Benson, Therwil, CH;

Konrad Bleicher, Freiburg, DE;

Alexander Chucholowski, San Diego, CA (US);

Henrietta Dehmlow, Grenzach-Wyhlen, DE;

Uwe Grether, Efringen-Kirchen, DE;

Bernd Kuhn, Liestal, CH;

Rainer E. Martin, Basel, CH;

Eric J. Niesor, Nyon, CH;

Narendra Panday, Munich, DE;

Hans Richter, Grenzach-Wyhlen, DE;

Franz Schuler, Riehen, CH;

Xavier Marie Warot, Strasbourg, FR;

Matthew Wright, Basel, CH;

Minmin Yang, Shanghai, CN;

Inventors:

Gregory Martin Benson, Therwil, CH;

Konrad Bleicher, Freiburg, DE;

Alexander Chucholowski, San Diego, CA (US);

Henrietta Dehmlow, Grenzach-Wyhlen, DE;

Uwe Grether, Efringen-Kirchen, DE;

Bernd Kuhn, Liestal, CH;

Rainer E. Martin, Basel, CH;

Eric J. Niesor, Nyon, CH;

Narendra Panday, Munich, DE;

Hans Richter, Grenzach-Wyhlen, DE;

Franz Schuler, Riehen, CH;

Xavier Marie Warot, Strasbourg, FR;

Matthew Wright, Basel, CH;

Minmin Yang, Shanghai, CN;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4184 (2006.01); C07D 235/04 (2006.01); C07D 235/18 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention is concerned with novel benzimidazole derivatives of formula (I) wherein Rto Rare as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to Farnesoid-X-receptors (FXR) and can be used to treat diseases which are modulated by FXR agonists such as diabetes and dyslipidemia.


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