The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2010
Filed:
Apr. 10, 2007
Patrizia Felicetti, Rome, IT;
Christopher Ingo Fincham, Pomezia, IT;
Alessandro Giolitti, Florence, IT;
Carlo Alberto Maggi, Florence, IT;
Laura Quartara, Florence, IT;
Cristina Rossi, Pomezia, IT;
Patrizia Felicetti, Rome, IT;
Christopher Ingo Fincham, Pomezia, IT;
Alessandro Giolitti, Florence, IT;
Carlo Alberto Maggi, Florence, IT;
Laura Quartara, Florence, IT;
Cristina Rossi, Pomezia, IT;
Abstract
Non-peptide compounds having activity as selective antagonists of bradykinin (BK) B2 receptor are disclosed. The compounds have the general formula (I) in which R is hydrogen or methyl; W is a single bond or an oxygen atom; n=3; X is hydrogen or a —NRRamino group in which Rand Rcan be independently hydrogen or a group which is methyl, ethyl, n-propyl, or isopropyl; Y is a —NRRRquaternary ammonium group in which RRRcan be independently a group which is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, or n-pentyl; and the enantiomers and enantiomeric mixtures thereof. Pharmaceutical compositions containing these compounds and methods of using the compounds to treat patients having conditions, disorders or diseases involving activation of bradykinin B2 receptors are also disclosed.