The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 12, 2010
Filed:
Oct. 04, 2007
Michael R. Knapp, Palo Alto, CA (US);
Jill M. Baker, Redwood City, CA (US);
Andrea W. Chow, Los Altos, CA (US);
Anne R. Kopf-sill, Portola Valley, CA (US);
Michael A. Spaid, Mountain View, CA (US);
Michael R. Knapp, Palo Alto, CA (US);
Jill M. Baker, Redwood City, CA (US);
Andrea W. Chow, Los Altos, CA (US);
Anne R. Kopf-Sill, Portola Valley, CA (US);
Michael A. Spaid, Mountain View, CA (US);
Caliper Life Sciences, Inc., Mountain View, CA (US);
Abstract
Methods for determining nucleic acid fragmentation status are provided. A nucleic acid of interest in a reaction mixture is contacted with two or more different probes complementary to sites separated by a point of potential fragmentation. The probes each comprise a detectable marker. The nucleic acid of interest is flowed into a detection region, where two or more coincident detectable marker signals from the probes are detected. Fragmentation status of the nucleic acid of interest is determined, coincident detection of signals from two or more of the different probes indicating the nucleic acid of interest is not fragmented between the probes.