The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2010
Filed:
Feb. 07, 2005
Jacob Hermanus Mattheus Hero Kooistra, Venlo, NL;
Hubertus Josephus Marie Zeegers, Baarlo, NL;
Daniel Mink, Eupen, BE;
Joannes Maria Cornelis Antonius Mulders, Geleen, NL;
Jacob Hermanus Mattheus Hero Kooistra, Venlo, NL;
Hubertus Josephus Marie Zeegers, Baarlo, NL;
Daniel Mink, Eupen, BE;
Joannes Maria Cornelis Antonius Mulders, Geleen, NL;
AstraZeneca UK Ltd., London, GB;
Abstract
The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula 1, where X stands for a leaving group, and R, R, and Reach independently stand for an alkyl group with 1-3 carbon atoms from 4-hydroxy-6-X-substituted-methyl-tetrahydropyran-2-one compounds, where X is as defined above, with the aid of an acetalization agent, in the presence of an acid catalyst. The invention also relates to the novel compounds of formula 1 as well as salts and acids to be prepared from these, with the ORgroup in formula 1 being replaced by an OY group, where X, Rand Rhave the meanings defined above and where Y stands for an alkaline (earth) metal or a substituted or unsubstituted ammonium group or stands for hydrogen, and to the novel compounds of formula 2. The products concerned are, after conversion into the t-butyl ester of 2-(6-hydroxymethyl-1,3-dioxane-4-yl)acetic acid, important as intermediary products in the preparation of statins.