The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2010
Filed:
Apr. 13, 2005
Xiaodong Wang, Chapel Hill, NC (US);
Kerry Leigh Spear, Concord, MA (US);
Alan Bradley Fulp, Willow Spring, NC (US);
Darrick Seconi, Cary, NC (US);
Takeshi Suzuki, Ibaraki, JP;
Takahiro Ishii, Ibaraki, JP;
Ayako Moritomo, Ibaraki, JP;
Xiaodong Wang, Chapel Hill, NC (US);
Kerry Leigh Spear, Concord, MA (US);
Alan Bradley Fulp, Willow Spring, NC (US);
Darrick Seconi, Cary, NC (US);
Takeshi Suzuki, Ibaraki, JP;
Takahiro Ishii, Ibaraki, JP;
Ayako Moritomo, Ibaraki, JP;
Icagen, Inc., Durham, NC (US);
Abstract
The present invention provides a genus of polycyclic pyrazines of formula (I): wherein A and B are independently substituted or unsubstituted 5- or 6- membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, Wis Wis —CH═, —NH—, —N═, —S—, or —O—; Zis Zis —CH═, —NH—, —N═, —S—, or —O—; Y is a bond, —CH═N—NH—, —NH—CH, or —NR—; s and t are independently integers from 1 to 4; and the substituents R, R, Rand Rare as defined in the specification for compounds of formula (I). The polycyclic pyrazine compounds are useful as modulators of potassium ion channels in both therapeutic and diagnostic methods.