The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2010
Filed:
Apr. 08, 2002
Robert C. Fahey, Del Mar, CA (US);
Gerald L. Newton, San Diego, CA (US);
Carole A. Bewley, Bethesda, MD (US);
Gillian Nicholas, Boulder, CO (US);
Robert C. Fahey, Del Mar, CA (US);
Gerald L. Newton, San Diego, CA (US);
Carole A. Bewley, Bethesda, MD (US);
Gillian Nicholas, Boulder, CO (US);
The Regents of the University of California, Oakland, CA (US);
National Institutes of Health, Bethesda, MD (US);
Abstract
The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring compounds obtained from marine sponges and other organisms. The invention further provides methods for using the compounds to inhibit virulence and reduce antibiotic resistance of mycothiol-producing bacteria.