Arylipiperdinopropanol and arylipiperazinopropanol derivatives and pharmaceuticals containing the same

Abstract

A compound having the formula (I) or its salt, hydrate, hydrate salt or solvate: wherein Rto Rindependently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl group, Rrepresents H, optionally substituted alkyl, aryl, or aralkyl group, Erepresents O, S, or —NR, where Rrepresents H, an optionally substituted alkyl, aryl, or aralkyl group, Erepresents O, S, or —NR, where Rrepresents H, an optionally substituted alkyl, aryl, or aralkyl group, A represents CH, C(OH), or N, X represents H, halogen, alkoxy, or an optionally substituted alkyl group, and Q represents an optionally substituted phenyl group, phenoxy, phenylmethyl, or cycloalkyloxy group, where when Erepresents O or S, Edoes not represent O or S, which has an action of suppressing the cytotoxic Caoverload and lipid peroxidation and effective for pharmaceutical preparation for the alleviation and treatment of symptoms due to ischemic diseases, etc.