The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 05, 2010

Filed:

Apr. 08, 2008
Applicants:

Taebo Sim, Seoul, KR;

Hyun Soo Lee, San Diego, CA (US);

Pingda Ren, San Diego, CA (US);

Qiang Ding, San Diego, CA (US);

Yi Liu, San Diego, CA (US);

Bing LI, Westborough, MA (US);

Lintong LI, San Diego, CA (US);

Xia Wang, San Diego, CA (US);

Tetsuo Uno, San Diego, CA (US);

Guobao Zhang, San Diego, CA (US);

Nathanael Schiander Gray, Boston, MA (US);

Shuli You, Shanghai, CN;

Inventors:

Taebo Sim, Seoul, KR;

Hyun Soo Lee, San Diego, CA (US);

Pingda Ren, San Diego, CA (US);

Qiang Ding, San Diego, CA (US);

Yi Liu, San Diego, CA (US);

Bing Li, Westborough, MA (US);

Lintong Li, San Diego, CA (US);

Xia Wang, San Diego, CA (US);

Tetsuo Uno, San Diego, CA (US);

Guobao Zhang, San Diego, CA (US);

Nathanael Schiander Gray, Boston, MA (US);

Shuli You, Shanghai, CN;

Assignee:

IRM LLC, Hamilton, BM;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); A61K 31/535 (2006.01); A61K 31/497 (2006.01); A61K 31/519 (2006.01); C07D 251/12 (2006.01); A61K 31/53 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.


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