The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 05, 2010
Filed:
May. 19, 2005
Tatiana I. Samoylova, Auburn, AL (US);
Henry J. Baker, Auburn, AL (US);
Nancy R. Cox, Auburn, AL (US);
Ludmila P. Globa, Auburn, AL (US);
Nancy E. Morrison, Auburn, AL (US);
Tatiana I. Samoylova, Auburn, AL (US);
Henry J. Baker, Auburn, AL (US);
Nancy R. Cox, Auburn, AL (US);
Ludmila P. Globa, Auburn, AL (US);
Nancy E. Morrison, Auburn, AL (US);
Auburn University, Auburn, AL (US);
Abstract
A diagnostic technique for matching anti-cancer peptide drugs to the molecular profiles of individual cancer tumors, and a method using the technique for a patient-specific treatment of tumors in mammals. This strategy matches anti-cancer peptide drugs to the molecular profiles of individual tumors, and includes the development of two banks, both of which use the same targeting peptides. Targeting peptides are identified using biopsies or other tissue materials from multiple cancer patients and placed into two banks. For a bank of probes, targeting peptides are linked to a label such as a fluorescent or a radioisotope. For a bank of drugs, targeting peptides are linked to a cytotoxic peptide to form a 'targeting peptide drug'. Peptide probes are used to establish molecular profiles of individual tumors. Based on these molecular profiles, a patient-specific combination of targeting drugs from the bank of peptide drugs is prepared and the patient is treated. Any currently used cytotoxic agent that can be linked to targeting peptides may be used in place of cytotoxic peptides.