Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents

Abstract

Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I) wherein Rthrough Rand Rthrough Rare defined herein, and α, β and γ are optional bonds, providing that when α is absent, β is present, and when β is absent, α is present. When α is present, preferred Rmoieties are selected from O, S, NH and CH, and when α is absent, preferred Rgroups are selected from OH, SH, NHand CH. When γ is present, the preferred Rsubstituent is O, while when γ is absent, the preferred Rsubstituent is OH. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.